To cite package ‘CREAM’ in publications use:

  Madani Tonekaboni S, Kofia V, Lupien M, Haibe-Kains B (2018). _CREAM:
  Clustering of Genomic Regions Analysis Method_. R package version
  1.1.1, <https://github.com/bhklab/cream>.

A BibTeX entry for LaTeX users is

  @Manual{,
    title = {CREAM: Clustering of Genomic Regions Analysis Method},
    author = {Seyed Ali {Madani Tonekaboni} and Victor Kofia and Mathieu Lupien and Benjamin Haibe-Kains},
    year = {2018},
    note = {R package version 1.1.1},
    url = {https://github.com/bhklab/cream},
  }